I think I have figured out why the Infotainment settings keep getting reset in my Bolt: Keypass/Bluetooth
If you have Keypass setup on your iPhone, the system usually greets you when you turn on the car. I noticed that when it didn't greet me, I had a different set of radio favorites and a different home screen layout. As an experiment, I started up the car, got the greeting message and went to the radio favorites screen. I turned off Bluetooth on the phone and the list of radio presets instantly changed and the radio station I was listening to changed. Turned back on Bluetooth, the phone connected to the system, I got the greet screen and things went back to the way they were. I'm guessing some settings are tied to which phone you are using. Toyota does this in the Highlander's infotainment system as well, but they explicitly tell you that it does that whereas Chevy seems to have neglected to tell us this.
I have not tried deleting the Keypass pairing with my iPhone to verify it's specifically an issue with Keypass, or if it's just a Bluetooth issue. I'll have to try that experiment tomorrow.