NeilBlanchard said:
Lighter vehicles have less kinetic energy at any given speed - so there is less energy that needs to be dissipated - making them safer, all else being equal.
The problem is that this means the deceleration forces are higher, and those are the forces that cause injury.
That doesn't matter if you're hitting a fixed object like a bridge abutment, because then it's up to the body design to gracefully dissipate momentum. A heavy vehicle can dissipate momentum just as well as a light vehicle can if it's designed properly.
But it does matter if you strike a moveable object (or if a moveable object strikes you). The heavier your vehicle is, the more energy will be transferred to whatever you're hitting (or, if you're being hit, the more it will resist that energy), which reduces the forces on you and makes the accident more survivable. This is especially important in t-bone collisions, because the brain is particularly susceptible to severe lateral acceleration.
Of course all of this presupposes an effective vehicle structure and restraint design.